Ubiquitin drives cilia shortening

Ubiquitin drives cilia shortening

Peroxisome inheritance at the right time and place E very yeast cell has numerous peroxi-somes—organelles that metabolize fatty acids— and roughly half are passed on to their daughter cells. Signaling from the bud to the mother cell ensures even peroxisome distribution by controlling the organelles' transport, say Fagarasanu et al. Peroxisomes travel into the bud along actin tracks using the my...

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

XPC recognizes UV-induced DNA lesions and initiates their removal by nucleotide excision repair (NER). Damage recognition in NER is tightly controlled by ubiquitin and SUMO modifications. Recent studies have shown that the SUMO-targeted ubiquitin ligase RNF111 promotes K63-linked ubiquitylation of SUMOylated XPC after DNA damage. However, the exact regulatory function of these modifications in ...

Integrin α1β1 Is Necessary For Primary Cilia Shortening In Response To Hypo- osmotic Stress

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane processes on the cell surface to function as a stable signaling apparatus. Here, we demonstrate that basal restriction of ciliary structure dynamics is established by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e....

The ubiquitin conjugation system is involved in the disassembly of cilia and flagella

The disassembly of cilia and flagella is linked to the cell cycle and environmental cues. We have found that ubiquitination of flagellar proteins is an integral part of flagellar disassembly. Free ubiquitin and the ubiquitin-conjugating enzyme CrUbc13 are detected in flagella, and several proteins are ubiquitinated in isolated flagella when exogenous ubiquitin and adenosine triphosphatase are a...